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Geography nerds amongst us rejoice: Silao is praised as the the exact geographic center of the nation, celebrated as the Cerro de Cubilete. More than that, Silao is central to a region known as the Bajío, which is now acknowledged as the heart of culture, architecture and archaeology in Mexico, and it plays an important part of the makeup of the state of Guanajuato.
Packed with churches and historical buildings, just strolling around the historic district will give you an appreciation of the history of colonial central Mexico. There are also some excellent museums, such as the Museo del Pueblo de Guanajuato (which, despite its name, is actually a modern art museum). Be sure to visit the Museo Jose y Tomás Chávez Moreldo, the Museo Iconografico del Quijote (a wonderful resource for all those who love Cervantes) and the Museo Exhacienda San Gabriela del Barrera, an enchanting hacienda.
The area is also the center of study of an unique pre-Columbian culture that is being excavated by many archaeological teams. The sites of Cañón ada de la Virgen, El Cóparo, Peralta and Plazuelas are still under current investigation. If you're interested in Mesoamerican cultures, you may - if you ask around - be able to arrange a tour of some of these sites.
Understand, though, that the name Silao is the great-great-grandchild of an ancient Mesoamerican term for "land of smoke"—meaning that humidity is a way of life. This is a tropical climate, so be prepared for light clothing, hats and lots of hydration. Take it slow, take it easy and enjoy the town.